Canagliflozin attenuates neurodegeneration and ameliorates dyskinesia through targeting the NLRP3/Nurr1/GSK-3β/SIRT3 pathway and autophagy modulation in rotenone-lesioned rats
Ahmed M Abdelaziz, Nora O. Abdel Rasheed, Hala F. Zaki, Hesham A. Salem, Rehab M. El‐Sayed
Topics & Concepts
NeurodegenerationRotenoneAutophagyPharmacologySIRT3DyskinesiaMedicineNeuroprotectionNeuroscienceParkinson's diseaseChemistryMitochondrionBiologyApoptosisInternal medicineBiochemistrySirtuinDiseaseAcetylationGeneParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingNerve injury and regeneration