ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
Zhenbo Han, Xiuxiu Wang, Zihang Xu, Yang Cao, Rui Gong, Yu Yang, Ying Yu, Xiaofei Guo, Shenzhen Liu, Meixi Yu, Wenya Ma, Yiming Zhao, Juan Xu, Xingda Li, Shuainan Li, Yan Xu, Ruijie Song, Binbin Xu, Fan Yang, Djibril Bamba, Natalia Sukhareva, Lei Hong, Manqi Gao, Wenwen Zhang, Н. Ш. Загидуллин, Ying Zhang, Baofeng Yang, Zhenwei Pan, Benzhi Cai
Abstract
A-YTHDF1-YAP axis in the regulation of CMs to re-enter the cell cycle. This finding suggests a novel potential therapeutic strategy for cardiac regeneration.
Topics & Concepts
DemethylaseBiologyRegeneration (biology)Downregulation and upregulationInduced pluripotent stem cellCell biologyMessenger RNAN6-MethyladenosineKnockout mouseHeart developmentCancer researchEmbryonic stem cellMethylationEpigeneticsReceptorMethyltransferaseGeneGeneticsRNA modifications and cancerCardiac Structural Anomalies and RepairHVDC Systems and Fault Protection