Long non‐coding <scp>RNAs</scp> in diabetic wound healing: Current research and clinical relevance
Le Kuai, Jingsi Jiang, Wei Li, Bin Li, Shuangyi Yin
Abstract
Diabetic wounds are a protracted complication of diabetes mainly characterised by chronic inflammation, obstruction of epithelialization, damaged blood vessels and collagen production (maturation), as well as neuropathy. As a non-coding RNA (ncRNA) that lack coding potential, long non-coding RNAs (lncRNAs) have recently been reported to play a salient role in diabetic wound healing. Here, this review summarises the roles of lncRNAs in the pathology and treatments of diabetic wounds, providing references for its potential clinical diagnostic criteria or therapeutic targets in the future.
Topics & Concepts
MedicineLong non-coding RNAWound healingDiabetes mellitusCoding (social sciences)Clinical significanceBioinformaticsInflammationDiabetic neuropathyDownregulation and upregulationSurgeryPathologyInternal medicineGeneEndocrinologyMathematicsBiochemistryBiologyStatisticsChemistryCancer-related molecular mechanisms researchDiabetic Foot Ulcer Assessment and ManagementWound Healing and Treatments