Tough and On‐Demand Detachable Wet Tissue Adhesive Hydrogel Made from Catechol Derivatives with a Long Aliphatic Side Chain
Yi‐Ming Chen, Peng Ni, Renfeng Xu, Xueli Wang, Chunhui Fu, Kaixuan Wan, Yan Fang, Haiqing Liu, Yunxiang Weng
Abstract
Abstract Wet adhesion is critical in cases of wound closure, but it is usually deterred by the hydration layer on tissues. Inspired by dopamine‐mediated underwater adhesion in mussel foot proteins, wet tissue adhesives containing catechol with 2–3 carbons side chains are reported mostly. To make wet adhesion of this type of adhesives much tougher, catechol derivatives with a long aliphatic side chain (≈10 atoms length) are synthesized. Then, a series of strong wet tissue adhesive hydrogels are prepared through photoinduced copolymerization of acrylic acid with synthetic monomers. The adhesive hydrogel has a high cohesion strength, that is, tensile strength and strain, and toughness of ≈1800 kPa, ≈540%, and ≈4100 kJ m −3 , respectively. Its interfacial toughness on wet and underwater porcine skin is respectively ≈1300 and ≈1100 J m −2 , and its adhesion strength to wet porcine skin is ≈153 kPa. These values are much higher than those of dopamine‐based adhesives in the same conditions, demonstrating that the long aliphatic side chain on catechol can greatly improve the wet tissue‐adhesion. Additionally, the tough interfacial adhesion can be broken on demand with 5 wt.% aqueous urea solution. This adhesive hydrogel is highly promising in safe wound closure.