Antiviral Bafilomycins from a Feces-Inhabiting <i>Streptomyces</i> sp.
Xi Xie, Shengsheng Lu, Xiaoyan Pan, Min Zou, Fangfang Li, Haixing Lin, Jianan Hu, Sheng Fan, Jian He
Abstract
A new bafilomycin derivative (1) and another seven known bafilomycins (2–8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
Topics & Concepts
FecesBafilomycinStreptomycesStreptomycetaceaeStereochemistryBiologyMicrobiologyAntiparasiticActinomycetalesDerivative (finance)VirologyChemistryBiochemistryBacteriaMedicineEconomicsGeneticsAutophagyApoptosisFinancial economicsPathologyPneumonia and Respiratory InfectionsAntibiotic Resistance in BacteriaCancer therapeutics and mechanisms