Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer
Hyewon Chung, Park Gyu-mi, Yi Rang Na, Yun‐Sang Lee, Hongyoon Choi, Seung Hyeok Seok
Abstract
These results provide comprehensive insights into TAM-mediated early tumor microenvironments and reveal immune evasion mechanisms that can be targeted by Gal-1 to induce antitumor immune responses.
Topics & Concepts
Tumor microenvironmentCancer researchImmune systemBiologyCD8Tumor progressionCancerImmunologyGeneticsGalectins and Cancer BiologyImmune cells in cancerPhagocytosis and Immune Regulation