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Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway

Wei Qi, Dong Ren, Pengcheng Wang, Zhao-Hui Song, Haotian Wu, Shuangquan Yao, Lindan Geng, Yunshan Su, Xiaoliang Bai

2020International Immunopharmacology38 citationsDOI

Topics & Concepts

Protein kinase BTyrosolDownregulation and upregulationPI3K/AKT/mTOR pathwayChemistryAggrecanCell biologyApoptosisMolecular biologyBiologyBiochemistryMedicineGenePathologyArticular cartilageAlternative medicineOsteoarthritisAntioxidantSpine and Intervertebral Disc PathologyPain Mechanisms and TreatmentsPlant Toxicity and Pharmacological Properties
Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway | Litcius