Chlamydia trachomatis TmeA Directly Activates N-WASP To Promote Actin Polymerization and Functions Synergistically with TarP during Invasion
Gabrielle Keb, Joshua Ferrell, Kaylyn R. Scanlon, Travis J. Jewett, Kenneth A. Fields
Abstract
infection, yet a thorough understanding of the molecular mechanisms initiating and orchestrating actin rearrangements has lagged. Our work highlights the application of genetic manipulation to address open questions regarding chlamydial invasion, a process essential to survival. We provide definitive insight regarding the role of the type III secreted effector TmeA and how that activity relates to another prominent effector, TarP. In addition, our data implicate at least one source that contributes to the functional divergence of entry mechanisms among chlamydial species.
Topics & Concepts
Chlamydia trachomatisActinDroneChlamydiaMicrobiologyPolymerizationWiskott–Aldrich syndrome proteinCell biologyBiologyChemistryVirologyImmunologyActin cytoskeletonCytoskeletonCellBiochemistryBotanyOrganic chemistryPolymerReproductive tract infections researchReproductive System and PregnancySexual function and dysfunction studies