A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles
Qixin Zhou, Xiaodan Li, Nan Gao, Guixia Ling, Peng Zhang
Abstract
wound healing, CIP/GOx@ZIF-8 MNs with good biosafety facilitated neovascularization and collagen deposition as well as reduced inflammation, and the wounds were almost healed after treatment. This multimodal therapeutic strategy is created to provide a unique treatment for infected diabetic wounds.
Topics & Concepts
Glucose oxidaseMaterials scienceBiocompatibilityNanocompositePolyvinylpyrrolidoneHydrogen peroxideGluconic acidBiomedical engineeringNuclear chemistryChemistryNanotechnologyMedicineBiosensorOrganic chemistryPolymer chemistryMetallurgyWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementPressure Ulcer Prevention and Management