Recent advances in fluorescence sensors based on DNA–MOF hybrids
Fen Wu, Jianhan Ye, Yulu Cao, Ziyuan Wang, Tingting Miao, Qian Shi
Abstract
In this review, the recent advances in the development of fluorescence sensors based on DNA and metal-organic framework hybrids have been reported for nucleic acid, metal ion and amino acid detection. The main detection mechanism depends on different adsorption capacities of MOFs towards different DNA structures (single-stranded DNA, double-stranded DNA), and consequently the fluorescence intensity of probe DNA is changed. These results might open up a way to study their potential application in material science and clinical diagnosis of some related diseases.
Topics & Concepts
DNAFluorescenceNucleic acidChemistryNanotechnologyPeptide nucleic acidMetal ions in aqueous solutionComputational biologyCombinatorial chemistryBiophysicsBiochemistryIonMaterials scienceBiologyOrganic chemistryPhysicsQuantum mechanicsAdvanced biosensing and bioanalysis techniquesMetal-Organic Frameworks: Synthesis and ApplicationsMolecular Sensors and Ion Detection