Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity
Jianan Sun, Jiahui Mu, Shenglin Wang, Jia Cai, Dahong Li, Huiming Hua, Hao Cao
Abstract
-chromen-3-yl)methyl)amino)-5-oxopentanamido)propanoate showed potent antitumor activities and relatively low side effects, and deserved further investigation.
Topics & Concepts
ChromoneChemistryApoptosisNitrogen mustardStereochemistryCell cultureAmino acidIntracellularSelectivityBiochemistryCancer researchPharmacologyBiologyMedicineChemotherapyInternal medicineGeneticsCyclophosphamideCatalysisSynthesis of Organic CompoundsSynthesis and biological activityClick Chemistry and Applications