A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition
Claudio Intini, Mark Lemoine, Tom Hodgkinson, Sarah Casey, John P. Gleeson, Fergal J. O'Brien
Abstract
by day 28. Taken together, the combination of CII and HyA resulted in the development of a biomimetic scaffold with improved chondrogenic benefits. These simple "off-the-shelf" implants hold great promise to direct enhanced tissue regeneration for the treatment of focal cartilage defects.
Topics & Concepts
ChondrogenesisScaffoldCartilageChemistryMesenchymal stem cellTissue engineeringRegeneration (biology)Biomedical engineeringMatrix (chemical analysis)Extracellular matrixType II collagenHyaluronic acidBiomaterialCell biologyAnatomyBiochemistryBiologyMedicineOrganic chemistryChromatographyOsteoarthritis Treatment and MechanismsCollagen: Extraction and CharacterizationPeriodontal Regeneration and Treatments