Immune microenvironment and fibroblast subpopulation in diabetic wound healing
Jing Gan, Yuanrong Chen, Lu Tang, Hui Dong, Xiaotang Gao, Yunfeng Huang, Pan Yang, Jing Han Hong, Zhibiao Bai, Xiong Chen, Zhuofeng Lin, Hong Zhu
Abstract
subpopulations. Fluorescence imaging confirmed these transcriptional changes at the protein level. This comprehensive profiling of the DFU repair microenvironment uncovers specific immune-fibroblast interactions that may underlie healing impairment, offering new directions for targeted therapeutic development.
Topics & Concepts
Wound healingImmune systemFibroblastImmunologyMedicineChemistryCell biologyBiologyBiochemistryIn vitroWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementPressure Ulcer Prevention and Management