MG53 inhibits ferroptosis by targeting the p53/SLC7A11/GPX4 pathway to alleviate doxorubicin-induced cardiotoxicity
Wenhua Jiang, Lu Yu, Nan Mu, Zihui Zhang, Heng Ma
Topics & Concepts
CardiotoxicityDoxorubicinGPX4Gene knockdownPharmacologyAnthracyclineCancer researchChemistryIn vivoUbiquitinApoptosisCell biologyMedicineGlutathione peroxidaseToxicityBiologyOxidative stressChemotherapyBiochemistryCancerInternal medicineSuperoxide dismutaseBreast cancerBiotechnologyGeneChemotherapy-induced cardiotoxicity and mitigationFerroptosis and cancer prognosisCircular RNAs in diseases