Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling
Suresh K. Mendu, Marta E. Stremska, Michael S. Schappe, Emily K. Moser, Julia K. Krupa, Jason S. Rogers, Eric J. Stipes, Clare A. Parker, Thomas J. Braciale, Justin S. A. Perry, Bimal N. Desai
Abstract
cell numbers, suggesting that it may be a therapeutic target to promote immune tolerance.
Topics & Concepts
TRPM7Cell biologyIon channelChemistrySignal transductionRegulatory T cellBiologyImmunologyT cellImmune systemBiochemistryIL-2 receptorReceptorIon Channels and Receptors