New thieno[3,2-d]pyrimidine-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents, EGFR and ARO inhibitors inducing apoptosis in breast cancer cells
A. M. FARGHALY, Omaima M. Aboulwafa, Hoda H. Baghdadi, Heba A. Abd El Razik, Samir M.Y. Sedra, Marium M. Shamaa
Topics & Concepts
ChemistryErlotinibApoptosisMCF-7PyrimidineCell cultureEGFR inhibitorsMTT assayCell growthIC50AnnexinIn vitroErlotinib HydrochlorideCell cycleBiochemistryStereochemistryPharmacologyCancer cellCancerEpidermal growth factor receptorReceptorHuman breastBiologyGeneticsSynthesis and biological activitySynthesis and Biological EvaluationCancer therapeutics and mechanisms