Rhodaelectro‐Catalyzed <i>peri</i> ‐Selective Direct Alkenylations with Weak <i>O</i> ‐Coordination Enabled by the Hydrogen Evolution Reaction (HER)
Bartłomiej Sadowski, Binbin Yuan, Zhipeng Lin, Lutz Ackermann
Abstract
)-directing groups. In sharp contrast, direct electrocatalytic transformations of weakly-coordinating phenols remain underdeveloped. Herein, electrooxidative peri C-H alkenylations of challenging 1-naphthols were achieved by versatile rhodium(III) catalysis via user-friendly constant current electrolysis. The rhodaelectrocatalysis employed readily-available alkenes and a protic reaction medium and features ample scope, good functional group tolerance and high site- and stereoselectivity. The strategy was successfully applied to high-value, nitrogen-containing heterocycles, thereby providing direct access to uncommon heterocyclic motifs based on the dihydropyranoquinoline skeleton.