Exploring the role of solvent polarity in mechanochemical Knoevenagel condensation: <i>in situ</i> investigation and isolation of reaction intermediates
Kerstin Scheurrell, Inês C. B. Martins, Claire A. Murray, Franziska Emmerling
Abstract
Raman spectroscopy and powder X-ray diffraction (PXRD). Our results indicate a direct relationship between solvent polarity and reaction kinetics, with higher solvent polarity leading to faster product (2-(4-nitrobenzylidone)malononitrile) formation. For the first time, we were able to isolate and determine the structure of an intermediate 2-(hydroxy(4-nitrophenyl)methyl)malononitrile based on PXRD data.
Topics & Concepts
Knoevenagel condensationMechanochemistryIn situPolarity (international relations)Solvent polarityChemistryIsolation (microbiology)Condensation reactionBiomimetic synthesisCondensationSolventOrganic chemistryNanotechnologyMaterials scienceCatalysisBiochemistryThermodynamicsPhysicsCellBiologyMicrobiologyX-ray Diffraction in CrystallographyCrystallography and molecular interactionsThermal and Kinetic Analysis