Tn5 DNA Transposase in Multi-Omics Research
Dmitry Penkov, Ekaterina Zubkova, Yelena Parfyonova
Abstract
Tn5 transposase use in biotechnology has substantially advanced the sequencing applications of genome-wide analysis of cells. This is mainly due to the ability of Tn5 transposase to efficiently transpose DNA essentially randomly into any target DNA without the aid of other factors. This concise review is focused on the advances in Tn5 applications in multi-omics technologies, genome-wide profiling, and Tn5 hybrid molecule creation. The possibilities of other transposase uses are also discussed.
Topics & Concepts
TransposaseComputational biologyGenomeTransposable elementBiologyTransposeDNATransposition (logic)DNA sequencingGeneticsComputer scienceGenePhysicsArtificial intelligenceQuantum mechanicsEigenvalues and eigenvectorsCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesChromosomal and Genetic Variations