Ruthenium(<scp>ii</scp>)-catalyzed amide directed spiroannulation with naphthoquinones: access to spiro-isoindolinone frameworks
Suman Dana, Chandan Kumar Giri, Mahiuddin Baidya
Abstract
A mild ruthenium(ii)-catalyzed spiroannulation between benzamides and naphthoquinones is developed for the succinct synthesis of biologically relevant spiro-isoindolinone scaffolds. A base promoted transannulation of spirocyclic products en route to valuable benzo[b]phenanthridinetriones in good yields has also been accomplished.
Topics & Concepts
CatalysisRutheniumAmideChemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic ChemistrySynthetic Organic Chemistry Methods