Tenosynovial and Cardiac Transthyretin Amyloidosis in Japanese Patients Undergoing Carpal Tunnel Release
Kenta Sugiura, Hiroki Kozuki, Hiroaki Ueba, Toru Kubo, Yuri Ochi, Yuichi Baba, Kazuya Miyagawa, Tatsuya Noguchi, Takayoshi Hirota, Naohito Yamasaki, Noriko Wada, Junko Nakashima, Ichiro Murakami, Masahiko Ikeuchi, Hiroaki Kitaoka
Abstract
Background:Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is a life-threatening progressive disease. Recent studies have shown that the detection of transthyretin (TTR) amyloid in tenosynovial tissue may play an important role in the diagnosis of cardiac amyloidosis. The aim of this study was to determine the prevalence of TTR amyloid deposits in surgical tissue of patients undergoing carpal tunnel surgery and to clarify the clinical significance of concomitant cardiac examination with 99 mTc-labeled pyrophosphate (99 mTc-PYP) scintigraphy in those patients with TTR deposition.