Concerted dispersion of <i>Staphylococcus aureus</i> biofilm by bacteriophage and ‘green synthesized’ silver nanoparticles
Salim Manoharadas, Mohammad Altaf, Abdulwahed Fahad Alrefaei, Rajesh Mamkulatil Devasia, Ahmed Yacine M. Badjah Hadj, Mohammed Saeed Ali Abuhasil
Abstract
biofilms from an inert glass surface in a time dependent manner. Our results demonstrate, for the first time, the rapid co-operative dispersion of the bacterial biofilm. In addition, the synergistic activity of the nanoparticles and bacteriophages causes the loss of viability of the biofilm entrapped bacterial cells thus preventing establishment of a new infection and subsequent colonization. This work further opens up a platform for the combinational therapeutic approach with a variety of nanoparticles and bacteriophages against mono or poly bacterial biofilm in environmental, industrial or clinical settings.