Electrochemical Difunctionalization of <i>gem</i>-Difluoroalkenes: A Metal-Free Synthesis of α-Difluoro(alkoxyl/azolated) Methylated Ethers
Linzi Wen, Naifu Zhou, Zhicheng Zhang, Cong Liu, Shihai Xu, Pengju Feng, Hongsheng Li
Abstract
-difluoroalkenes to structurally versatile difluoro motifs was achieved. This methodology features reagent-free conditions, good functional group tolerance, and a relatively broad substrate scope. Meanwhile, the electrolysis protocol is easy to handle, and the products show good regio- and chemoselectivity. The reaction mechanism was also preliminarily studied.
Topics & Concepts
ChemistryChemoselectivityCombinatorial chemistryElectrolysisReagentElectrochemistrySubstrate (aquarium)Alkoxy groupFunctional groupOrganic chemistryCatalysisAlkylElectrolyteOceanographyPhysical chemistryGeologyElectrodePolymerFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods