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IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Imran G. House, Junyun Lai, Amanda X. Y. Chen, Kirsten L. Todd, Emma V. Petley, Sherly Mardiana, Izabela Todorovski, Emily Gruber, Madison J. Kelly, Benjamin Solomon, Stephin J. Vervoort, Ricky W. Johnstone, Ian A. Parish, Paul J. Neeson, Lev M. Kats, Phillip K. Darcy, Paul A. Beavis

2020Molecular Therapy107 citationsDOIOpen Access PDF

Topics & Concepts

Chimeric antigen receptorCancer researchT cellCD28ImmunologyBlockadeCD8ImmunotherapyMedicineCytotoxic T cellImmune systemBiologyReceptorInternal medicineIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune Responses
IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors | Litcius