Blockade of Indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression
Lei Gao, Tingting Gao, Ting Zeng, Peng Huang, Nai-Kei Wong, Zhaoyang Dong, Yunjia Li, Guanghui Deng, Zhiyong Wu, Zhiping Lv
Abstract
exerted stress resistance and decreased the sensitivity of depression in CUMS mice with the stable BOLD signals, BDNF expression and neurogenesis in hippocampus. Thus, IDO1 hyperactivity played crucial roles in modulating 5-HT metabolism and BDNF function thereby impacting outcomes of hippocampal neurogenesis and BOLD signals in depressive disorder.
Topics & Concepts
NeurogenesisHippocampal formationHippocampusDorsal raphe nucleusNeuroscienceEndocrinologyInternal medicinePsychologyIndoleamine 2,3-dioxygenaseMedicineChemistrySerotoninSerotonergicReceptorTryptophanBiochemistryAmino acidTryptophan and brain disordersStress Responses and CortisolBipolar Disorder and Treatment