Effect of histamine-receptor antagonism on leg blood flow during exercise
Matthew R. Ely, Stephen M. Ratchford, D. Taylor La Salle, Joel D. Trinity, D. Walter Wray, John R. Halliwill
Abstract
Leg blood flow during exercise was increased by taking antihistamines, which block the receptors for histamine, a molecule often associated with inflammatory and immune responses. The elevated blood flow occurred over exercise intensities ranging from 20 to 80% of peak capacity and during exercise of 60 min duration. These results suggest that exercise-induced elevations in histamine concentrations are involved in novel, poorly understood, and perhaps complex ways in the exercise response.
Topics & Concepts
HistamineAntagonismBlood flowPhysical exerciseInternal medicineReceptorMedicineEndocrinologyHistamine receptorHistamine H2 receptorHistamine H1 receptorChemistryPharmacologyAntagonistExercise and Physiological ResponsesPharmacological Effects and AssaysCardiovascular and exercise physiology