Functional Analysis of the Expanded Phosphodiesterase Gene Family in Toxoplasma gondii Tachyzoites
William J. Moss, Caitlyn E. Patterson, Alexander K. Jochmans, Kevin M. Brown
Abstract
Apicomplexan parasites require motility to actively infect host cells and cause disease. Cyclic nucleotide signaling governs apicomplexan motility, but it is unclear how cyclic nucleotide levels are maintained in these parasites.
Topics & Concepts
BiologyToxoplasma gondiiCell biologyMotilityProtein kinase APhosphodiesteraseKinaseCyclic nucleotide phosphodiesteraseExtracellularSignal transductionEntamoeba histolyticaBiochemistryGeneticsEnzymeAntibodyToxoplasma gondii Research StudiesCarbohydrate Chemistry and SynthesisPhosphodiesterase function and regulation