A core–shell liquid metal-Cu nanoparticle with glutathione consumption<i>via</i>an<i>in situ</i>replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy
Yongnian Yu, Qiong Wu, Meng Niu, Li Gou, Longfei Tan, Changhui Fu, Xiangling Ren, Jun Ren, Yongfa Zheng, Xianwei Meng
Abstract
replacement reaction. A stable core-shell liquid-metal based "Cu storage pool" was obtained. It can effectively deplete GSH within the cells, and simultaneously produce ·OH through a Fenton-like reaction, further improving the effect of chemodynamic therapy (CDT). Under microwave irradiation, it is also capable of producing a large amount of ROS to promote tumor treatment. In addition, the loading of ionic liquid endows LZC@IL nanoparticles with certain microwave heating performance, which is able to augment microwave thermal therapy (MWTT). With the combination of CDT, microwave dynamic therapy (MDT) and MWTT, LZC@IL has an excellent effect on tumor elimination. This work offers a new idea for the application of liquid metals and the combined treatment of tumors, which has potential application value.