Biodegradable Patches for Arterial Reconstruction Modified with RGD Peptides: Results of an Experimental Study
В В Севостьянова, Л. В. Антонова, А. В. Миронов, Arseniy E. Yuzhalin, Vladimir N. Silnikov, Т. В. Глушкова, Tatyana S. Godovikova, E. O. Krivkina, Evgeny Bolbasov, T. N. Akentyeva, M. Yu. Khanova, В. Г. Матвеева, Е. А. Великанова, Р. С. Тарасов, Л. С. Барбараш
Abstract
of KemPeriplas-Neo patches were 4- and 16.7-times higher than those made of human internal mammary artery, respectively. Both RGD-modified and unmodified PHBV/PCL patches demonstrated properties similar to a human internal mammary artery patch. Regardless of RGD modification, experimental PHBV/PCL patches displayed fewer lysed red blood cells and resulted in milder platelet aggregation than KemPeriplas-Neo patches. Xenopericardial patches failed to form an endothelial layer in vivo and were prone to calcification. By contrast, TTDDA/RGDK-modified biodegradable patches demonstrated a resistance to calcification. Modification by TTDDA/RGDK and TTDDA/c[RGDFK] facilitated the formation of neovasculature upon the implantation in vivo.