The fabrication strategies for chitosan/poly(vinyl pyrrolidone) based hydrogels and their biomedical applications: A focused review
Muhammad Asim Raza, Khurram Shahzad, Shiv Dutt Purohit, Sang Hyun Park, Sung Soo Han
Abstract
Chitosan (CS) and poly(vinyl pyrrolidone) (PVP) blend provide enhanced mechanical properties, biocompatibility, stability, antimicrobial properties, and versatility in fabrication. Due to these inherent biocompatible and antimicrobial properties, CS/PVP based hydrogels have been used in various biomedical applications. Herein, we have provided an overview of the recent developments in the fabrication of CS/PVP hydrogels and their nanocomposite with better structural and functional properties. Combining CS/PVP with nano-architectures results in amendments in the structure and properties of the CS/PVP matrices. Hence, recent developments in using CS/PVP hydrogels and their nanocomposites for drug delivery, protein/gene delivery, and wound healing applications are described here.