A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
Mingming Li, Yue Zhang, Yujia Guan, Zunwei Zhang, Hanbing Dong, Zhao Yang, Hui Deng
Abstract
As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40-60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.
Topics & Concepts
DiseaseMedicineHematopoietic stem cell transplantationGraft-versus-host diseaseCentral nervous systemIncidence (geometry)TransplantationImmune systemRare diseasePathologyImmunologySurgeryInternal medicinePhysicsOpticsHematopoietic Stem Cell TransplantationMultiple Sclerosis Research StudiesAcute Myeloid Leukemia Research