Pyrrole synthesis through Cu-catalyzed cascade [3 + 2] spiroannulation/aromatization of oximes with azadienes
Jing Lin, Ting-Yu Zheng, Nengquan Fan, Pu Zhang, Kun Jiang, Ye Wei
Abstract
We disclose an efficient synthetic protocol for the assembly of poly-substituted pyrroles through cascade [3 + 2] spiroannulation/aromatization of oximes with azadienes.
Topics & Concepts
AromatizationChemistryCascadePyrroleCatalysisCombinatorial chemistryOrganic chemistryChromatographySynthesis and Characterization of PyrrolesCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry