I<sub>2</sub>/TBHP-mediated oxidative cascade cyclization of vinyl azide and benzylamine to construct 2,5-disubstituted oxazoles
Mohanreddy Pothireddy, Rana Chatterjee, P. Vijaya Babu, Rambabu Dandela
Abstract
)-functionalization with the elimination of the azide group as the intermediate step. In consequence, the consecutive C-N and C-O bond formations lead to a variety of disubstituted oxazole derivatives. Moreover, the one-pot methodology features a metal-free strategy, readily available reagents, shorter times, good yields, and mild reaction conditions.
Topics & Concepts
ChemistryBenzylamineCascadeAzideOxidative phosphorylationConstruct (python library)Combinatorial chemistryOrganic chemistryChromatographyBiochemistryComputer scienceProgramming languageCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms