Harnessing regulatory T cells to establish immune tolerance
Patrick Ho, Ellen Cahir-McFarland, Jason D. Fontenot, Tracey Lodie, Adel Nada, Qizhi Tang, Laurence A. Turka, Jeffrey A. Bluestone
Abstract
Engineered regulatory T (T reg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T reg cell therapies in treating autoimmune and other inflammatory diseases.
Topics & Concepts
Immune toleranceImmune systemImmunosuppressionRegulatory T cellTreg cellImmunologySelf ToleranceRegulatory B cellsMedicineAutoimmunityBiologyT cellInterleukin 10IL-2 receptorT-cell and B-cell ImmunologyImmune Cell Function and InteractionCAR-T cell therapy research