Electrochemical trifluoromethylation of 2-isocyanobiaryls using CF<sub>3</sub>SO<sub>2</sub>Na: synthesis of 6-(trifluoromethyl)phenanthridines
Kannika La‐ongthong, Teera Chantarojsiri, Darunee Soorukram, Pawaret Leowanawat, Vichai Reutrakul, Chutima Kuhakarn
Abstract
Na) as the trifluoromethyl source. The method enabled the syntheses of a series of 6-(trifluoromethyl)phenanthridine derivatives in moderate to high yields under metal- and oxidant-free conditions. A gram-scale synthesis highlights the synthetic versatility of the reported protocol.
Topics & Concepts
TrifluoromethylationTrifluoromethylPhenanthridineChemistryElectrolysisElectrochemistryCombinatorial chemistryOrganic chemistryPhysical chemistryElectrodeElectrolyteAlkylFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesRadical Photochemical Reactions