Multidimensional Delivery Strategies for Liposomal Transdermal Drug Delivery Systems
Chengyun Wang, Yanhui Wang, Xinyue Lan, Longjiao Zhu, Jianhua Gu, Weichen Hou, Baiqiang Zhai, Dantong Li, Hongtao Tian, Wentao Xu
Abstract
Currently, the main challenge in transdermal drug delivery systems is the skin barrier. Liposomes have emerged as a crucial tool for overcoming this challenge, due to their efficient penetration through the skin barrier. A comprehensive summary of each aspect of the liposome transdermal delivery system has been reviewed in this paper. While elucidating the liposome transdermal mechanism, the effects of membrane materials, preparation methods, and various surface modification strategies on liposome transdermal drug delivery systems were further discussed in detail. Furthermore, the article critically points out limitations in liposome transdermal penetration and introduced the penetration-enhancing mechanisms of six different penetration-enhancing technologies, such as microneedle, electroporation, iontophoresis, laser introduction, magnetic introduction, and ultrasonic introduction, along with their specific applications. Finally, the research progress in transdermal treatment has been systematically summarized. We hope that this article will serve as a valuable reference and source of inspiration for professional researchers in related fields.