Role of the Prognostic Nutritional Index in Patients With Soft-tissue Sarcoma
Yumi Matsuyama, Tomoki Nakamura, Keisuke Yoshida, Kōichi Nakamura, Tomohito Hagi, Kunihiro Asanuma, Akihiro Sudo
Abstract
BACKGROUND: This study aimed to determine whether the prognostic nutritional index (PNI) can predict the prognosis in patients with soft-tissue sarcoma (STS) before treatment and to examine whether there is an association between PNI values and clinical characteristics. PATIENTS AND METHODS: The data on 100 patients with primary STS were retrospectively reviewed. The cohort included 55 men and 45 women, with a mean age of 64 years. The mean follow-up duration was 41.7 months. RESULTS: The median PNI was 51.35. The PNI was significantly inversely associated with tumor size, tumor grade, and age. We found that the PNI was a significant prognostic marker for disease-specific and event-free survival using univariate and multivariate analyses. Patients with a low PNI had poorer disease-specific and event-free survival than those with a high PNI. CONCLUSION: These results suggest that the PNI can be used as a prognostic marker in patients with STS.