Design, synthesis and biological evaluation of novel pyrazinone derivatives as PI3K/HDAC dual inhibitors
Zi-Xiao Wang, Shuai Wang, Xue-Peng Qiao, Wenbo Li, Jian-Tao Shi, Yiru Wang, Shi‐Wu Chen
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayAcetylationHDAC6IC50Protein kinase BIn vitroBiochemistryApoptosisHistone deacetylaseHistoneGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsUbiquitin and proteasome pathways