A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan‐Fan Ding
Abstract
particles per μL. The employed methodology achieved notable success in accurately distinguishing breast cancer patients from healthy individuals through serum analysis. The application of this method showcases the significant potential for early exosome analysis in the clinical diagnosis of breast cancer patients.
Topics & Concepts
Click chemistryAptamerBiosensorCD63FluorescenceMicrovesiclesAzideAlkyneChemistryPolymerCombinatorial chemistryMolecular biologyBiochemistryBiologyOrganic chemistrymicroRNAQuantum mechanicsCatalysisPhysicsGeneAdvanced biosensing and bioanalysis techniquesExtracellular vesicles in diseaseGold and Silver Nanoparticles Synthesis and Applications