Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy
Yoshihide Hattori, Miki Ishimura, Youichirou Ohta, Hiroshi Takenaka, Shinji Kawabata, Mitsunori Kirihata
Abstract
We developed novel closo-dodecaborate ([B12H11]2–) anion-containing translocator protein (TSPO) ligand as a boron carrier for boron neutron capture therapy. This compound shows high water solubility and can deliver boron to TSPO highly expressed in breast cancer cells. We describe the synthesis and in vitro evaluation of a dodecaborate-based pyrazolopyrimidine.
Topics & Concepts
Translocator proteinBoronChemistryLigand (biochemistry)Neutron captureCombinatorial chemistryConjugateIn vitroRadiochemistryBiochemistryMedicineOrganic chemistryInternal medicineReceptorMathematicsMathematical analysisNeuroinflammationInflammationBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsBoron and Carbon Nanomaterials Research