miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma
Anup S. Pathania, Philip Prathipati, Omalla A. Olwenyi, Srinivas Chava, Oghenetejiri V. Smith, Subash C. Gupta, Nagendra K. Chaturvedi, Siddappa N. Byrareddy, Donald W. Coulter, Kishore B. Challagundla
Abstract
T and NK cell-mediated anti-tumor responses. These findings demonstrate that miR-15a and miR-15b induce an anti-tumor immune response by targeting PD-L1 in NB.
Topics & Concepts
NeuroblastomaImmune systemCancer researchCD8Cytotoxic T cellChemistryBiologyImmunologyCell cultureBiochemistryGeneticsIn vitroNeuroblastoma Research and TreatmentsImmune Cell Function and InteractionLung Cancer Research Studies