Sulfur-fluoride exchange (SuFEx)-enabled lead discovery of AChE inhibitors by fragment linking strategies
Ziwen Zhang, Shilong Zhang, Chengyao Wu, Huanhuan Li, Liang Zha, Jingbo Shi, Xinhua Liu, Hua‐Li Qin, Wenjian Tang
Topics & Concepts
ChemistryDrug discoverySmall moleculeCombinatorial chemistryLead compoundPotencySulfonylFragment (logic)Ligand efficiencySulfonamideComputational biologyStereochemistryIn vitroBiochemistryLigand (biochemistry)Organic chemistryReceptorAlkylBiologyComputer scienceProgramming languageClick Chemistry and ApplicationsChemical Synthesis and AnalysisSulfur-Based Synthesis Techniques