Palladium-Catalyzed Ring-Opening Defluorinative Hiyama Cross-Coupling of <i>gem</i>-Difluorocyclopropanes with Arylsilanes
Zhi-Shang Wang, Dong-Guo Hong, Hongfang Li, Teck‐Peng Loh, Mingzhu Lu
Abstract
We report an efficient palladium-catalyzed ring-opening defluorinative Hiyama cross-coupling of gem -difluorocyclopropanes with structurally diverse (hetero)arylsilanes through C–C bond activation and C–F bond cleavage. This regioselective ring-opening defluorinative Hiyama cross-coupling features a broad substrate scope with excellent functional group compatibility, affording a diverse variety of linear 2-fluoroallylic scaffolds in good yields with high Z -selectivity.
Topics & Concepts
PalladiumRing (chemistry)ChemistryCoupling (piping)Polymer chemistryCatalysisMaterials scienceOrganic chemistryComposite materialFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions