Modular synthesis of fluorinated 2<i>H</i>-thiophenes <i>via</i> [4 + 1] cyclization of enaminothiones
Xinyu Zhang, Jinli Zhang, Jie Chen, Bang-Hua Zhou, Jian Zhang, Shunhong Chen, Jian Wu, Yaojia Jiang
Abstract
-tosylhydrazones has been disclosed. The cycloaddition platforms were found to be compatible with a broad substrate scope and to show high regio- and stereo-selectivities under very mild reaction conditions such as room temperature, neutral media and low loading of catalyst.
Topics & Concepts
ChemistryTrifluoromethylCycloadditionSubstrate (aquarium)Scope (computer science)CatalysisCombinatorial chemistryModular designMedicinal chemistryOrganic chemistryStereochemistryProgramming languageComputer scienceAlkylGeologyOceanographyFluorine in Organic ChemistryCyclopropane Reaction MechanismsSulfur-Based Synthesis Techniques