Palladium- and Brønsted acid-catalyzed enantio-, site- and <i>E</i>/<i>Z</i>-selective addition of alkylidenecyclopropanes with imines
Xin‐Lian Liu, Han-Ze Lin, Lu-Qi Tan, Jin‐Bao Peng
Abstract
An enantio-, site- and E / Z -selective addition of ACPs with imines for the synthesis of dienyl substituted amines has been developed via palladium- and Brønsted acid co-catalysis.
Topics & Concepts
CatalysisPalladiumChemistryNucleophileTransition metalCycloadditionBrønsted–Lowry acid–base theoryNucleophilic additionOrganic chemistryCombinatorial chemistryMetalCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods