Design and characterisation of ZIF-8/alginate composites as drug carrier systems
Sarah V. Dummert, Sylvia Dörschmidt, Theresa Bloehs, Katia Rodewald, Miriam Caviglia, Claudia Schmidt, Mian Zahid Hussain, Julien Warnan, Roland A. Fischer, Angela Casini, Romy Ettlinger
Abstract
preliminary studies of the antiproliferative activity of ThT@ZIF-8@Alg in cancerous and non-tumorigenic cells support the idea of sustained controlled release of ThT over 72 h at pH 7.4. This strategy advances MOF-hydrogel-based drug delivery systems, with potential applications in topical treatments and implant coatings.
Topics & Concepts
Materials scienceComposite materialMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers