Ruthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides: substrate keeps the catalyst active
Han‐Jun Ai, Yang Yuan, Xiao‐Feng Wu
Abstract
The electron pair of the heteroatom in heterocycles will coordinate with metal catalysts and decrease or even inhibit their catalytic activity consequently. In this work, a pincer ruthenium-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides has been developed. Benefitting from the pincer ligand, a variety of heterocycles, such as thiophenes, morpholine, unprotected indoles, pyrrole, pyridine, pyrimidine, furan, thiazole, pyrazole, benzothiadiazole, and triazole, are compatible here.
Topics & Concepts
Pincer movementRutheniumCatalysisSubstrate (aquarium)AlkylChemistryCombinatorial chemistryOrganic chemistryBiologyEcologyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysis