Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC) by Functionalized NHC-Based Polynuclear Catalysts: Scope and Mechanistic Insights
Miguel González-Lainez, Miguel Gallegos, Julen Munárriz, Ramón Azpíroz, Vincenzo Passarelli, M. Victoria Jiménez, Jesús J. Pérez‐Torrente
Abstract
)], resulting from the fragmentation of the tetranuclear compound, as the catalytically active species. The proposed reaction pathway proceeds through zwitterionic dinuclear intermediates and entails the active participation of both copper atoms, as well as the NHC moiety as an internal base, which activates the reacting alkyne via deprotonation.
Topics & Concepts
ChemistryCycloadditionCatalysisAlkyneAzideCopperScope (computer science)Combinatorial chemistryOrganic chemistryPolymer chemistryProgramming languageComputer scienceClick Chemistry and ApplicationsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling Reactions