Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction
Hyun-Doo Song, Sang Nam Kim, Abhirup Saha, Sang-Yeop Ahn, Seun Akindehin, Yeonho Son, Yoon Keun Cho, Minsu Kim, Ji Hyun Park, Young-Suk Jung, Yun-Hee Lee
Abstract
KO mice showed reduced expression of aging-induced inflammation and senescence markers in eWAT. Collectively, these results identified the upregulation of pro-BDNF expression in adipocyte progenitors as a feature of visceral white adipose tissue aging and suggested that inhibition of BDNF expression in adipocyte progenitors is potentially beneficial to prevent aging-related adipose tissue dysfunction.
Topics & Concepts
AdipocyteInternal medicineEndocrinologyAdipose tissueWhite adipose tissueBrain-derived neurotrophic factorDownregulation and upregulationSenescenceNeurotrophic factorsProgenitor cellAdipose tissue macrophagesBiologyMedicineCell biologyStem cellReceptorBiochemistryGeneAdipose Tissue and MetabolismSirtuins and Resveratrol in MedicineNerve injury and regeneration