<scp>Pd‐Catalyzed</scp> Asymmetric Synthesis of 3,<scp>4‐Dihydroisoquinolinones</scp> From <scp><i>N</i>‐Ts‐Benzamides</scp> and 1,<scp>3‐Dienes</scp>
Tae‐Kyun Kim, So Won Youn
Abstract
A Pd(II)-catalyzed asymmetric oxidative annulation of N-Ts-benzamides with 1,3-dienes using a chiral pyridine-oxazoline-type ligand for the regio- and stereoselective synthesis of chiral 3,4-dihydroisoquinolinones has been developed. Appendix S1: supporting information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Topics & Concepts
ChemistryAnnulationCatalysisLigand (biochemistry)StereochemistryCombinatorial chemistryStereoselectivityPyridineOxazolineMedicinal chemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality SynthesisChemical synthesis and alkaloids